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Methylergometrine maleate Tablet I.P.
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Methylergometrine maleate Tablet I.P.

Methylergometrine maleate tablet is a medication used to prevent or control postpartum hemorrhage (excessive bleeding after childbirth) and to manage certain gynecological conditions. It is also known as Methylergonovine maleate tablet and is available under various brand names.

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Methylergometrine maleate tablet is a medication used to prevent or control postpartum hemorrhage (excessive bleeding after childbirth) and to manage certain gynecological conditions. It is also known as Methylergonovine maleate tablet and is available under various brand names.

Here’s some key information about Methylergometrine maleate tablet:

  1. Indications:
    • Prevention and treatment of postpartum hemorrhage: After childbirth, the uterus contracts to expel the placenta and reduce bleeding. Methylergometrine helps to enhance uterine contractions, thereby reducing the risk of excessive bleeding.
    • Management of postpartum hemorrhage: If bleeding does occur after childbirth, Methylergometrine can be used to help control it.
    • Treatment of postpartum uterine atony: This condition refers to the inability of the uterus to contract effectively after childbirth, leading to hemorrhage. Methylergometrine can help stimulate uterine contractions in such cases.
  2. Mechanism of Action: Methylergometrine acts primarily by stimulating uterine smooth muscle contractions. It binds to and activates specific receptors (alpha-adrenergic and serotonin receptors) on the smooth muscle cells of the uterus, leading to increased tone and decreased bleeding.
  3. Dosage: The dosage of Methylergometrine maleate tablets varies depending on the specific indication and the healthcare provider’s recommendation. It is typically administered orally, usually as a single tablet or as directed by a healthcare professional.
  4. Contraindications: Methylergometrine maleate tablets are contraindicated in certain situations, including hypersensitivity to the medication, hypertension (high blood pressure), pre-eclampsia, eclampsia, and coronary artery disease. It should be used with caution in patients with hepatic impairment or renal insufficiency.
  5. Side Effects: Common side effects of Methylergometrine maleate tablets may include nausea, vomiting, abdominal cramps, headache, dizziness, and hypertension. In rare cases, more serious side effects such as uterine hypertonicity, seizures, and stroke may occur.
  6. Precautions:
    • Methylergometrine should be administered cautiously in patients with a history of hypertension or cardiovascular disease.
    • It should not be used prophylactically in patients with a history of severe hypertension, pre-eclampsia, or eclampsia.
    • Monitoring of blood pressure is recommended during administration.
  7. Pregnancy and Lactation: Methylergometrine may be used during pregnancy and lactation under the supervision of a healthcare professional when indicated. However, it should be used with caution during pregnancy, particularly in the first trimester.

As with any medication, it’s important to use Methylergometrine maleate tablets under the guidance of a qualified healthcare provider and to follow their instructions regarding dosage, administration, and monitoring for potential side effects.

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